Publications
1.
Wang, Li-Ping; Yuan, Yang; Liu, Ying-Le; Lu, Qing-Bin; Shi, Lu-Sha; Ren, Xiang; Zhou, Shi-Xia; Zhang, Hai-Yang; Zhang, Xiao-Ai; Wang, Xin; Wang, Yi-Fei; Lin, Sheng-Hong; Zhang, Cui-Hong; Geng, Meng-Jie; Li, Jun; Zhao, Shi-Wen; Yi, Zhi-Gang; Chen, Xiao; Yang, Zuo-Sen; Meng, Lei; Wang, Xin-Hua; Cui, Ai-Li; Lai, Sheng-Jie; and others,
Etiological and epidemiological features of acute meningitis or encephalitis in China: a nationwide active surveillance study Journal Article
In: The Lancet Regional Health-Western Pacific, vol. 20, no. 100361, 2022.
Abstract | Links | BibTeX | Tags: Asia, China, Demographic and Health Surveys, infectious disease
@article{nokey,
title = {Etiological and epidemiological features of acute meningitis or encephalitis in China: a nationwide active surveillance study},
author = {Wang, Li-Ping and Yuan, Yang and Liu, Ying-Le and Lu, Qing-Bin and Shi, Lu-Sha and Ren, Xiang and Zhou, Shi-Xia and Zhang, Hai-Yang and Zhang, Xiao-Ai and Wang, Xin and Wang, Yi-Fei and Lin, Sheng-Hong and Zhang, Cui-Hong and Geng, Meng-Jie and Li, Jun and Zhao, Shi-Wen and Yi, Zhi-Gang and Chen, Xiao and Yang, Zuo-Sen and Meng, Lei and Wang, Xin-Hua and Cui, Ai-Li and Lai, Sheng-Jie and and others},
doi = {https://doi.org/10.1016/j.lanwpc.2021.100361},
year = {2022},
date = {2022-01-03},
urldate = {2022-01-03},
journal = {The Lancet Regional Health-Western Pacific},
volume = {20},
number = {100361},
abstract = {Acute meningitis or encephalitis (AME) results from a neurological infection causing high case fatality and severe sequelae. AME lacked comprehensive surveillance in China.
Methods
Nation-wide surveillance of all-age patients with AME syndromes was conducted in 144 sentinel hospitals of 29 provinces in China. Eleven AME-causative viral and bacterial pathogens were tested with multiple diagnostic methods.
Findings
Between 2009 and 2018, 20,454 AME patients were recruited for tests. Based on 9,079 patients with all-four-virus tested, 28.43% (95% CI: 27.50%‒29.36%) of them had at least one virus-positive detection. Enterovirus was the most frequently determined virus in children <18 years, herpes simplex virus and Japanese encephalitis virus were the most frequently determined in 18−59 and ≥60 years age groups, respectively. Based on 6,802 patients with all-seven-bacteria tested, 4.43% (95% CI: 3.94%‒4.91%) had at least one bacteria-positive detection, Streptococcus pneumoniae and Neisseria meningitidis were the leading bacterium in children aged <5 years and 5−17 years, respectively. Staphylococcus aureus was the most frequently detected in adults aged 18−59 and ≥60 years. The pathogen spectrum also differed statistically significantly between northern and southern China. Joinpoint analysis revealed age-specific positive rates, with enterovirus, herpes simplex virus and mumps virus peaking at 3−6 years old, while Japanese encephalitis virus peaked in the ≥60 years old. As age increased, the positive rate for Streptococcus pneumoniae and Escherichia coli statistically significantly decreased, while for Staphylococcus aureus and Streptococcus suis it increased.
Interpretation
The current findings allow enhanced identification of the predominant AME-related pathogen candidates for diagnosis in clinical practice and more targeted application of prevention and control measures in China, and a possible reassessment of vaccination strategy.},
keywords = {Asia, China, Demographic and Health Surveys, infectious disease},
pubstate = {published},
tppubtype = {article}
}
Acute meningitis or encephalitis (AME) results from a neurological infection causing high case fatality and severe sequelae. AME lacked comprehensive surveillance in China.
Methods
Nation-wide surveillance of all-age patients with AME syndromes was conducted in 144 sentinel hospitals of 29 provinces in China. Eleven AME-causative viral and bacterial pathogens were tested with multiple diagnostic methods.
Findings
Between 2009 and 2018, 20,454 AME patients were recruited for tests. Based on 9,079 patients with all-four-virus tested, 28.43% (95% CI: 27.50%‒29.36%) of them had at least one virus-positive detection. Enterovirus was the most frequently determined virus in children <18 years, herpes simplex virus and Japanese encephalitis virus were the most frequently determined in 18−59 and ≥60 years age groups, respectively. Based on 6,802 patients with all-seven-bacteria tested, 4.43% (95% CI: 3.94%‒4.91%) had at least one bacteria-positive detection, Streptococcus pneumoniae and Neisseria meningitidis were the leading bacterium in children aged <5 years and 5−17 years, respectively. Staphylococcus aureus was the most frequently detected in adults aged 18−59 and ≥60 years. The pathogen spectrum also differed statistically significantly between northern and southern China. Joinpoint analysis revealed age-specific positive rates, with enterovirus, herpes simplex virus and mumps virus peaking at 3−6 years old, while Japanese encephalitis virus peaked in the ≥60 years old. As age increased, the positive rate for Streptococcus pneumoniae and Escherichia coli statistically significantly decreased, while for Staphylococcus aureus and Streptococcus suis it increased.
Interpretation
The current findings allow enhanced identification of the predominant AME-related pathogen candidates for diagnosis in clinical practice and more targeted application of prevention and control measures in China, and a possible reassessment of vaccination strategy.
Methods
Nation-wide surveillance of all-age patients with AME syndromes was conducted in 144 sentinel hospitals of 29 provinces in China. Eleven AME-causative viral and bacterial pathogens were tested with multiple diagnostic methods.
Findings
Between 2009 and 2018, 20,454 AME patients were recruited for tests. Based on 9,079 patients with all-four-virus tested, 28.43% (95% CI: 27.50%‒29.36%) of them had at least one virus-positive detection. Enterovirus was the most frequently determined virus in children <18 years, herpes simplex virus and Japanese encephalitis virus were the most frequently determined in 18−59 and ≥60 years age groups, respectively. Based on 6,802 patients with all-seven-bacteria tested, 4.43% (95% CI: 3.94%‒4.91%) had at least one bacteria-positive detection, Streptococcus pneumoniae and Neisseria meningitidis were the leading bacterium in children aged <5 years and 5−17 years, respectively. Staphylococcus aureus was the most frequently detected in adults aged 18−59 and ≥60 years. The pathogen spectrum also differed statistically significantly between northern and southern China. Joinpoint analysis revealed age-specific positive rates, with enterovirus, herpes simplex virus and mumps virus peaking at 3−6 years old, while Japanese encephalitis virus peaked in the ≥60 years old. As age increased, the positive rate for Streptococcus pneumoniae and Escherichia coli statistically significantly decreased, while for Staphylococcus aureus and Streptococcus suis it increased.
Interpretation
The current findings allow enhanced identification of the predominant AME-related pathogen candidates for diagnosis in clinical practice and more targeted application of prevention and control measures in China, and a possible reassessment of vaccination strategy.
2.
Jia, Peng; Dong, Weihua; Yang, Shujuan; Zhan, Zhicheng; Tu, La; Lai, Shengjie
Spatial Lifecourse Epidemiology and Infectious Disease Research Journal Article
In: Trends in Parasitology, vol. 36, no. 3, pp. 235-238, 2020, ISSN: 1471-4922.
Abstract | Links | BibTeX | Tags: infectious disease, spatial analysis, spatial lifecourse epidemiology
@article{JIA2020235,
title = {Spatial Lifecourse Epidemiology and Infectious Disease Research},
author = {Peng Jia and Weihua Dong and Shujuan Yang and Zhicheng Zhan and La Tu and Shengjie Lai},
url = {https://www.sciencedirect.com/science/article/pii/S1471492220300052},
doi = {https://doi.org/10.1016/j.pt.2019.12.012},
issn = {1471-4922},
year = {2020},
date = {2020-01-01},
journal = {Trends in Parasitology},
volume = {36},
number = {3},
pages = {235-238},
abstract = {Spatial lifecourse epidemiology aims to utilize advanced spatial, location-aware, and artificial intelligence technologies to investigate long-term effects of measurable biological, environmental, behavioral, and psychosocial factors on individual risk for chronic diseases. It could also further the research on infectious disease dynamics, risks, and consequences across the life course.},
keywords = {infectious disease, spatial analysis, spatial lifecourse epidemiology},
pubstate = {published},
tppubtype = {article}
}
Spatial lifecourse epidemiology aims to utilize advanced spatial, location-aware, and artificial intelligence technologies to investigate long-term effects of measurable biological, environmental, behavioral, and psychosocial factors on individual risk for chronic diseases. It could also further the research on infectious disease dynamics, risks, and consequences across the life course.
