@article{,

title = {Assessing spread risk of COVID-19 within and beyond China in early 2020},

author = {Lai, Shengjie and Bogoch, Isaac I and Ruktanonchai, Nick W and Watts, Alexander and Lu, Xin and Yang, Weizhong and Yu, Hongjie and Khan, Kamran and Tatem, Andrew J},

doi = {10.1016/j.dsm.2022.08.004},

year  = {2022},

date = {2022-08-26},

urldate = {2022-08-26},

journal = {Data Science and Management},

abstract = {A novel coronavirus emerged in Wuhan in late 2019 and has caused the COVID-19 pandemic announced by the World Health Organization on March 12, 2020. This study was originally conducted in January 2020 to estimate the potential risk and geographic range of COVID-19 spread within and beyond China at the early stage of the pandemic. A series of connectivity and risk analyses based on domestic and international travel networks were conducted using historical aggregated mobile phone data and air passenger itinerary data. We found that the cordon sanitaire of Wuhan was likely to have occurred during the latter stages of peak population numbers leaving the city, with travellers departing into neighbouring cities and other megacities in China. We estimated that 59,912 air passengers, of which 834 (95% uncertainty interval: 478–1349) had COVID-19 infection, travelled from Wuhan to 382 cities outside of mainland China during the two weeks prior to the city’s lockdown. Most of these destinations were located in Asia, but major hubs in Europe, the US and Australia were also prominent, with a strong correlation seen between the predicted risks of importation and the number of imported cases found. Given the limited understanding of emerging infectious diseases in the very early stages of outbreaks, our approaches and findings in assessing travel patterns and risk of transmission can help guide public health preparedness and intervention design for new COVID-19 waves caused by variants of concern and future pandemics to effectively limit transmission beyond its initial extent.},

keywords = {China, covid-19, Mobility},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Etiological and epidemiological features of acute meningitis or encephalitis in China: a nationwide active surveillance study},

author = {Wang, Li-Ping and Yuan, Yang and Liu, Ying-Le and Lu, Qing-Bin and Shi, Lu-Sha and Ren, Xiang and Zhou, Shi-Xia and Zhang, Hai-Yang and Zhang, Xiao-Ai and Wang, Xin and Wang, Yi-Fei and Lin, Sheng-Hong and Zhang, Cui-Hong and Geng, Meng-Jie and Li, Jun and Zhao, Shi-Wen and Yi, Zhi-Gang and Chen, Xiao and Yang, Zuo-Sen and Meng, Lei and Wang, Xin-Hua and Cui, Ai-Li and Lai, Sheng-Jie and and others},

doi = {https://doi.org/10.1016/j.lanwpc.2021.100361},

year  = {2022},

date = {2022-01-03},

urldate = {2022-01-03},

journal = {The Lancet Regional Health-Western Pacific},

volume = {20},

number = {100361},

abstract = {Acute meningitis or encephalitis (AME) results from a neurological infection causing high case fatality and severe sequelae. AME lacked comprehensive surveillance in China.

Methods

Nation-wide surveillance of all-age patients with AME syndromes was conducted in 144 sentinel hospitals of 29 provinces in China. Eleven AME-causative viral and bacterial pathogens were tested with multiple diagnostic methods.

Findings

Between 2009 and 2018, 20,454 AME patients were recruited for tests. Based on 9,079 patients with all-four-virus tested, 28.43% (95% CI: 27.50%‒29.36%) of them had at least one virus-positive detection. Enterovirus was the most frequently determined virus in children <18 years, herpes simplex virus and Japanese encephalitis virus were the most frequently determined in 18−59 and ≥60 years age groups, respectively. Based on 6,802 patients with all-seven-bacteria tested, 4.43% (95% CI: 3.94%‒4.91%) had at least one bacteria-positive detection, Streptococcus pneumoniae and Neisseria meningitidis were the leading bacterium in children aged <5 years and 5−17 years, respectively. Staphylococcus aureus was the most frequently detected in adults aged 18−59 and ≥60 years. The pathogen spectrum also differed statistically significantly between northern and southern China. Joinpoint analysis revealed age-specific positive rates, with enterovirus, herpes simplex virus and mumps virus peaking at 3−6 years old, while Japanese encephalitis virus peaked in the ≥60 years old. As age increased, the positive rate for Streptococcus pneumoniae and Escherichia coli statistically significantly decreased, while for Staphylococcus aureus and Streptococcus suis it increased.

Interpretation

The current findings allow enhanced identification of the predominant AME-related pathogen candidates for diagnosis in clinical practice and more targeted application of prevention and control measures in China, and a possible reassessment of vaccination strategy.},

keywords = {Asia, China, Demographic and Health Surveys, infectious disease},

pubstate = {published},

tppubtype = {article}

}